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Anti-apoptotic Ras signalling cascade
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Anti-apoptotic Ras signalling cascade : ウィキペディア英語版
Anti-apoptotic Ras signalling cascade
The Anti-apoptotic Ras signaling cascade is an intracellular signal transduction cascade
that involves the Ras protein and inhibits apoptosis. It is the target of the cancer drug gefitinib.
It may refer to the PI3K/AKT pathway.
〔http://genesdev.cshlp.org/content/11/6/701.abstract "The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal" 1997〕
〔http://www.springerlink.com/content/86l52127046nx383/ 2Hypoinsulinemia Alleviates the Grf1/Ras/Akt Anti-Apoptotic Pathway and Induces Alterations of Mitochondrial Ras Trafficking in Neuronal Cells" 2009〕
It may refer to the MAPK/ERK pathway which involves ras and can affect apoptosis.〔http://cancerres.aacrjournals.org/cgi/content/abstract/67/21/10343 "Suppression of PTEN Expression Is Essential for Antiapoptosis and Cellular Transformation by Oncogenic Ras" 2007〕
〔http://www.aacrmeetingabstracts.org/cgi/content/abstract/2005/1/972-b "Pathways potentiated by oncogenic Ras to modulate apoptosis induced by anticancer agent FR901228 " 2005〕
The anti-apoptotic STAT pathway does not involve Ras.
==See also==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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